SPRB

Spruce Biosciences, Inc.$51.72+2.62 (+5.33%)

Prev Close$49.10·MCap$36.0M·P/E—·Vol58.5K·Yield—

▲

Buys (12M)

$0.00

▼

Sells (12M)

$771.4K

◆

Net Activity

Net Seller

$771.4K

●

Active Insiders

last 12 mo

Over the past 12 months, insider activity at Spruce Biosciences, Inc. (SPRB) has been exclusively selling, with 0 insider purchases totaling $0.00 and 6 insider sales totaling $771.4K. The most recent insider transaction was by Gharib Samir M. (PRESIDENT AND CFO), who sold $29.2K worth of shares on Dec 15, 2025. Spruce Biosciences, Inc. operates in the Healthcare sector, within the Biotechnology industry, with a market cap of $36.0M.

SPRB Insider Trading Activity

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Dec 15, 2025	Gharib Samir M.	PRESIDENT AND CFO	Sell	362	$80.67	$29.2K	0
Dec 11, 2025	Szwarcberg Javier B.	CHIEF EXECUTIVE OFFICER	Sell	1,360	$80.67	$109.7K	0
Dec 10, 2025	Gharib Samir M.	PRESIDENT AND CFO	Sell	864	$87.83	$75.9K	0
Dec 10, 2025	Szwarcberg Javier B.	CHIEF EXECUTIVE OFFICER	Sell	2,622	$87.96	$230.6K	0
Oct 20, 2025	Gharib Samir M.	PRESIDENT AND CFO	Sell	661	$148.16	$97.9K	0
Oct 20, 2025	Szwarcberg Javier B.	CHIEF EXECUTIVE OFFICER	Sell	1,539	$148.16	$228.0K	0
Mar 25, 2024	Novo Holdings A/S	10% Owner	Sell	465,021	$0.75	$351.0K80.1% OS	2,550,000
Mar 20, 2024	Novo Holdings A/S	10% Owner	Sell	1,794,999	$0.76	$1.36M309.3% OS	3,968,000-31%
Mar 18, 2024	Novo Holdings A/S	10% Owner	Sell	1,912,316	$0.89	$1.70M329.5% OS	4,810,020-28%
May 16, 2023	O'Donnell Niall	Director	Buy	630,400	$3.17	$2.00M108.6% OS	1,326,305+91%
Feb 21, 2023	Novo Holdings A/S	10% Owner	Buy	2,208,000	$3.17	$7.00M380.5% OS	6,722,336+49%
May 21, 2021	Novo Holdings A/S	10% Owner	Sell	475,000	$13.90	$6.60M81.8% OS	4,514,336
May 21, 2021	SIMPSON CAMILLA V	Director	Sell	334	$15.29	$5.1K	0Exit
May 4, 2021	SIMPSON CAMILLA V	Director	Sell	14,045	$16.14	$226.7K2.4% OS	0Exit

SPRB Insider Buying Activity

The following table shows recent insider purchases of Spruce Biosciences, Inc. (SPRB) stock reported via SEC Form 4 filings.

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
May 16, 2023	O'Donnell Niall	Director	Buy	630,400	$3.17	$2.00M108.6% OS	1,326,305+91%
Feb 21, 2023	Novo Holdings A/S	10% Owner	Buy	2,208,000	$3.17	$7.00M380.5% OS	6,722,336+49%

SPRB Insider Selling Activity

The following table shows recent insider sales of Spruce Biosciences, Inc. (SPRB) stock reported via SEC Form 4 filings.

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Dec 15, 2025	Gharib Samir M.	PRESIDENT AND CFO	Sell	362	$80.67	$29.2K	0
Dec 11, 2025	Szwarcberg Javier B.	CHIEF EXECUTIVE OFFICER	Sell	1,360	$80.67	$109.7K	0
Dec 10, 2025	Gharib Samir M.	PRESIDENT AND CFO	Sell	864	$87.83	$75.9K	0
Dec 10, 2025	Szwarcberg Javier B.	CHIEF EXECUTIVE OFFICER	Sell	2,622	$87.96	$230.6K	0
Oct 20, 2025	Gharib Samir M.	PRESIDENT AND CFO	Sell	661	$148.16	$97.9K	0
Oct 20, 2025	Szwarcberg Javier B.	CHIEF EXECUTIVE OFFICER	Sell	1,539	$148.16	$228.0K	0
Mar 25, 2024	Novo Holdings A/S	10% Owner	Sell	465,021	$0.75	$351.0K80.1% OS	2,550,000
Mar 20, 2024	Novo Holdings A/S	10% Owner	Sell	1,794,999	$0.76	$1.36M309.3% OS	3,968,000-31%
Mar 18, 2024	Novo Holdings A/S	10% Owner	Sell	1,912,316	$0.89	$1.70M329.5% OS	4,810,020-28%
May 21, 2021	Novo Holdings A/S	10% Owner	Sell	475,000	$13.90	$6.60M81.8% OS	4,514,336
May 21, 2021	SIMPSON CAMILLA V	Director	Sell	334	$15.29	$5.1K	0Exit
May 4, 2021	SIMPSON CAMILLA V	Director	Sell	14,045	$16.14	$226.7K2.4% OS	0Exit