SION
Sionna Therapeutics, Inc.$3.70-0.17 (-4.39%)Prev Close$3.87·MCap$174.7M·P/E—·Vol131.5K·Yield—
▲
Buys (12M)
0
$0.00
▼
Sells (12M)
21
$128.01M
◆
Net Activity
Net Seller
$128.01M
●
Active Insiders
4
last 12 mo
Over the past 12 months, insider activity at Sionna Therapeutics, Inc. (SION) has been exclusively selling, with 0 insider purchases totaling $0.00 and 21 insider sales totaling $128.01M. The most recent insider transaction was by RA CAPITAL MANAGEMENT, L.P. (director, 10 percent owner: ), who sold $21.84M worth of shares on Sep 21, 2026. Sionna Therapeutics, Inc. operates in the Healthcare sector, within the Biotechnology industry, with a market cap of $174.7M.
SION Insider Trading Activity
| Date | Insider | Role | Type | Shares | Avg Price | Value | Shares After |
|---|---|---|---|---|---|---|---|
| Sep 21, 2026 | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Sell | 3,448,811 | $6.33 | $21.84M7.6% OS | 3,482,612-50% |
| Jul 9, 2026 | Thompson Peter A. | director | Sell | 85,918 | $44.86 | $3.85M | 2,469,959 |
| Jul 9, 2026 | ORBIMED ADVISORS LLC | director | Sell | 85,918 | $44.86 | $3.85M | 2,469,959 |
| Jul 7, 2026 | Fitzpatrick Jennifer | officer: Chief Legal Officer | Sell | 10,250 | $43.60 | $446.9K | 0Exit |
| Jul 2, 2026 | ORBIMED ADVISORS LLC | director | Sell | 115,844 | $45.50 | $5.27M | 2,555,877 |
| Jul 2, 2026 | Thompson Peter A. | director | Sell | 115,844 | $45.50 | $5.27M | 2,555,877 |
| May 29, 2026 | ORBIMED ADVISORS LLC | director | Sell | 101 | $44.49 | $4.5K | 2,671,721 |
| May 29, 2026 | Thompson Peter A. | director | Sell | 101 | $44.49 | $4.5K | 2,671,721 |
| May 11, 2026 | ORBIMED ADVISORS LLC | director | Sell | 292,952 | $45.62 | $13.36M0.7% OS | 2,916,228 |
| May 11, 2026 | Thompson Peter A. | director | Sell | 292,952 | $45.62 | $13.36M0.7% OS | 2,916,228 |
| Apr 21, 2026 | Thompson Peter A. | director | Sell | 55,345 | $44.67 | $2.47M | 2,967,722 |
| Apr 21, 2026 | ORBIMED ADVISORS LLC | director | Sell | 55,345 | $44.67 | $2.47M | 2,967,722 |
| Apr 16, 2026 | ORBIMED ADVISORS LLC | director | Sell | 510,583 | $44.94 | $22.95M1.1% OS | 3,482,888 |
| Apr 16, 2026 | Thompson Peter A. | director | Sell | 510,583 | $44.94 | $22.95M1.1% OS | 3,482,888 |
| Mar 6, 2026 | Fitzpatrick Jennifer | officer: Chief Legal Officer | Sell | 10,250 | $33.86 | $347.0K | 0Exit |
| Feb 4, 2026 | ORBIMED ADVISORS LLC | director | Sell | 30,953 | $44.58 | $1.38M | 3,559,765 |
| Feb 2, 2026 | Thompson Peter A. | Director | Sell | 30,953 | $44.58 | $1.38M | 0 |
| Dec 24, 2025 | Thompson Peter A. | Director | Sell | 33,356 | $44.55 | $1.49M | 0 |
| Dec 17, 2025 | Thompson Peter A. | Director | Sell | 1,875 | $44.49 | $83.4K | 0 |
| Dec 5, 2025 | Fitzpatrick Jennifer | Chief Legal Officer | Sell | 10,250 | $40.52 | $415.3K | 0 |
| Nov 24, 2025 | Thompson Peter A. | Director | Sell | 108,073 | $44.55 | $4.81M | 0 |
| Oct 21, 2025 | Cloonan Michael | President & CEO | Sell | 99,800 | $36.26 | $3.62M | 0 |
| Oct 21, 2025 | Booth Bruce | Director | Sell | 88,878 | $34.22 | $3.04M | 0 |
| Oct 16, 2025 | Booth Bruce | Director | Sell | 286,369 | $32.30 | $9.25M0.6% OS | 0 |
| Oct 15, 2025 | Cloonan Michael | President & CEO | Sell | 25,200 | $31.28 | $788.2K | 0 |
| Oct 10, 2025 | Booth Bruce | Director | Sell | 194,932 | $30.47 | $5.94M | 0 |
| Oct 3, 2025 | Booth Bruce | Director | Sell | 49,546 | $29.99 | $1.49M | 0 |
| Sep 29, 2025 | Booth Bruce | Director | Sell | 78,693 | $30.08 | $2.37M | 0 |
| Sep 26, 2025 | Cloonan Michael | President & CEO | Sell | 25,000 | $29.11 | $727.8K | 0 |
| Sep 4, 2025 | Fitzpatrick Jennifer | Chief Legal Officer | Sell | 10,250 | $23.12 | $237.0K | 0 |
| Aug 29, 2025 | Ridloff Elena | CFO & Head of Corp. Dev. | Sell | 9,584 | $25.09 | $240.4K | 0 |
| Aug 26, 2025 | Ridloff Elena | CFO & Head of Corp. Dev. | Sell | 23,416 | $25.70 | $601.9K | 0 |
| Aug 26, 2025 | Cloonan Michael | President & CEO | Sell | 25,000 | $24.97 | $624.4K | 0 |
| Aug 20, 2025 | Cloonan Michael | President & CEO | Sell | 25,000 | $22.75 | $568.8K | 0 |
| Aug 19, 2025 | Ridloff Elena | CFO & Head of Corp. Dev. | Sell | 52,000 | $21.62 | $1.12M | 0 |
| Feb 12, 2025 | TPG GP A, LLC | 10% Owner | Buy | 1,125,000 | $18.00 | $20.25M2.5% OS | 6,684,962 |
| Feb 10, 2025 | RA CAPITAL MANAGEMENT, L.P. | Buy | 1,125,000 | $18.00 | $20.25M2.5% OS | 6,923,365 | |
| Feb 10, 2025 | ORBIMED ADVISORS LLC | Director | Buy | 550,000 | $18.00 | $9.90M1.2% OS | 3,704,959 |
| Feb 10, 2025 | Booth Bruce | Buy | 60,000 | $18.00 | $1.08M | 807,727 |
SION Insider Buying Activity
The following table shows recent insider purchases of Sionna Therapeutics, Inc. (SION) stock reported via SEC Form 4 filings.
| Date | Insider | Role | Type | Shares | Avg Price | Value | Shares After |
|---|---|---|---|---|---|---|---|
| Feb 12, 2025 | TPG GP A, LLC | 10% Owner | Buy | 1,125,000 | $18.00 | $20.25M2.5% OS | 6,684,962 |
| Feb 10, 2025 | RA CAPITAL MANAGEMENT, L.P. | Buy | 1,125,000 | $18.00 | $20.25M2.5% OS | 6,923,365 | |
| Feb 10, 2025 | ORBIMED ADVISORS LLC | Director | Buy | 550,000 | $18.00 | $9.90M1.2% OS | 3,704,959 |
| Feb 10, 2025 | Booth Bruce | Buy | 60,000 | $18.00 | $1.08M | 807,727 |
SION Insider Selling Activity
The following table shows recent insider sales of Sionna Therapeutics, Inc. (SION) stock reported via SEC Form 4 filings.
| Date | Insider | Role | Type | Shares | Avg Price | Value | Shares After |
|---|---|---|---|---|---|---|---|
| Sep 21, 2026 | RA CAPITAL MANAGEMENT, L.P. | director, 10 percent owner: | Sell | 3,448,811 | $6.33 | $21.84M7.6% OS | 3,482,612-50% |
| Jul 9, 2026 | Thompson Peter A. | director | Sell | 85,918 | $44.86 | $3.85M | 2,469,959 |
| Jul 9, 2026 | ORBIMED ADVISORS LLC | director | Sell | 85,918 | $44.86 | $3.85M | 2,469,959 |
| Jul 7, 2026 | Fitzpatrick Jennifer | officer: Chief Legal Officer | Sell | 10,250 | $43.60 | $446.9K | 0Exit |
| Jul 2, 2026 | ORBIMED ADVISORS LLC | director | Sell | 115,844 | $45.50 | $5.27M | 2,555,877 |
| Jul 2, 2026 | Thompson Peter A. | director | Sell | 115,844 | $45.50 | $5.27M | 2,555,877 |
| May 29, 2026 | ORBIMED ADVISORS LLC | director | Sell | 101 | $44.49 | $4.5K | 2,671,721 |
| May 29, 2026 | Thompson Peter A. | director | Sell | 101 | $44.49 | $4.5K | 2,671,721 |
| May 11, 2026 | ORBIMED ADVISORS LLC | director | Sell | 292,952 | $45.62 | $13.36M0.7% OS | 2,916,228 |
| May 11, 2026 | Thompson Peter A. | director | Sell | 292,952 | $45.62 | $13.36M0.7% OS | 2,916,228 |
| Apr 21, 2026 | Thompson Peter A. | director | Sell | 55,345 | $44.67 | $2.47M | 2,967,722 |
| Apr 21, 2026 | ORBIMED ADVISORS LLC | director | Sell | 55,345 | $44.67 | $2.47M | 2,967,722 |
| Apr 16, 2026 | ORBIMED ADVISORS LLC | director | Sell | 510,583 | $44.94 | $22.95M1.1% OS | 3,482,888 |
| Apr 16, 2026 | Thompson Peter A. | director | Sell | 510,583 | $44.94 | $22.95M1.1% OS | 3,482,888 |
| Mar 6, 2026 | Fitzpatrick Jennifer | officer: Chief Legal Officer | Sell | 10,250 | $33.86 | $347.0K | 0Exit |
| Feb 4, 2026 | ORBIMED ADVISORS LLC | director | Sell | 30,953 | $44.58 | $1.38M | 3,559,765 |
| Feb 2, 2026 | Thompson Peter A. | Director | Sell | 30,953 | $44.58 | $1.38M | 0 |
| Dec 24, 2025 | Thompson Peter A. | Director | Sell | 33,356 | $44.55 | $1.49M | 0 |
| Dec 17, 2025 | Thompson Peter A. | Director | Sell | 1,875 | $44.49 | $83.4K | 0 |
| Dec 5, 2025 | Fitzpatrick Jennifer | Chief Legal Officer | Sell | 10,250 | $40.52 | $415.3K | 0 |
| Nov 24, 2025 | Thompson Peter A. | Director | Sell | 108,073 | $44.55 | $4.81M | 0 |
| Oct 21, 2025 | Cloonan Michael | President & CEO | Sell | 99,800 | $36.26 | $3.62M | 0 |
| Oct 21, 2025 | Booth Bruce | Director | Sell | 88,878 | $34.22 | $3.04M | 0 |
| Oct 16, 2025 | Booth Bruce | Director | Sell | 286,369 | $32.30 | $9.25M0.6% OS | 0 |
| Oct 15, 2025 | Cloonan Michael | President & CEO | Sell | 25,200 | $31.28 | $788.2K | 0 |
| Oct 10, 2025 | Booth Bruce | Director | Sell | 194,932 | $30.47 | $5.94M | 0 |
| Oct 3, 2025 | Booth Bruce | Director | Sell | 49,546 | $29.99 | $1.49M | 0 |
| Sep 29, 2025 | Booth Bruce | Director | Sell | 78,693 | $30.08 | $2.37M | 0 |
| Sep 26, 2025 | Cloonan Michael | President & CEO | Sell | 25,000 | $29.11 | $727.8K | 0 |
| Sep 4, 2025 | Fitzpatrick Jennifer | Chief Legal Officer | Sell | 10,250 | $23.12 | $237.0K | 0 |
| Aug 29, 2025 | Ridloff Elena | CFO & Head of Corp. Dev. | Sell | 9,584 | $25.09 | $240.4K | 0 |
| Aug 26, 2025 | Ridloff Elena | CFO & Head of Corp. Dev. | Sell | 23,416 | $25.70 | $601.9K | 0 |
| Aug 26, 2025 | Cloonan Michael | President & CEO | Sell | 25,000 | $24.97 | $624.4K | 0 |
| Aug 20, 2025 | Cloonan Michael | President & CEO | Sell | 25,000 | $22.75 | $568.8K | 0 |
| Aug 19, 2025 | Ridloff Elena | CFO & Head of Corp. Dev. | Sell | 52,000 | $21.62 | $1.12M | 0 |
SION Insiders
RA CAPITAL MANAGEMENT, L.P.
director, 10 percent owner:
Bought $20.25MSold $21.84M
2 tradesLast: Sep 21, 2026
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