SION

Sionna Therapeutics, Inc.$35.93-0.12 (-0.33%)

Prev Close$36.05·MCap$1.54B·P/E—·Vol111.5K·Yield—

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Buys (12M)

$0.00

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Sells (12M)

$118.09M

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Net Activity

Net Seller

$118.09M

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Active Insiders

last 12 mo

Over the past 12 months, insider activity at Sionna Therapeutics, Inc. (SION) has been exclusively selling, with 0 insider purchases totaling $0.00 and 29 insider sales totaling $118.09M. The most recent insider transaction was by ORBIMED ADVISORS LLC (director), who sold $4.5K worth of shares on May 29, 2026. Sionna Therapeutics, Inc. operates in the Healthcare sector, within the Biotechnology industry, with a market cap of $1.54B.

SION Insider Trading Activity

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
May 29, 2026	ORBIMED ADVISORS LLC	director	Sell	101	$44.49	$4.5K	2,671,721
May 29, 2026	Thompson Peter A.	director	Sell	101	$44.49	$4.5K	2,671,721
May 11, 2026	ORBIMED ADVISORS LLC	director	Sell	292,952	$45.62	$13.36M0.7% OS	2,916,228
May 11, 2026	Thompson Peter A.	director	Sell	292,952	$45.62	$13.36M0.7% OS	2,916,228
Apr 21, 2026	Thompson Peter A.	director	Sell	55,345	$44.67	$2.47M	2,967,722
Apr 21, 2026	ORBIMED ADVISORS LLC	director	Sell	55,345	$44.67	$2.47M	2,967,722
Apr 16, 2026	ORBIMED ADVISORS LLC	director	Sell	510,583	$44.94	$22.95M1.1% OS	3,482,888
Apr 16, 2026	Thompson Peter A.	director	Sell	510,583	$44.94	$22.95M1.1% OS	3,482,888
Mar 6, 2026	Fitzpatrick Jennifer	officer: Chief Legal Officer	Sell	10,250	$33.86	$347.0K	0Exit
Feb 4, 2026	ORBIMED ADVISORS LLC	director	Sell	30,953	$44.58	$1.38M	3,559,765
Feb 2, 2026	Thompson Peter A.	Director	Sell	30,953	$44.58	$1.38M	0
Dec 24, 2025	Thompson Peter A.	Director	Sell	33,356	$44.55	$1.49M	0
Dec 17, 2025	Thompson Peter A.	Director	Sell	1,875	$44.49	$83.4K	0
Dec 5, 2025	Fitzpatrick Jennifer	Chief Legal Officer	Sell	10,250	$40.52	$415.3K	0
Nov 24, 2025	Thompson Peter A.	Director	Sell	108,073	$44.55	$4.81M	0
Oct 21, 2025	Cloonan Michael	President & CEO	Sell	99,800	$36.26	$3.62M	0
Oct 21, 2025	Booth Bruce	Director	Sell	88,878	$34.22	$3.04M	0
Oct 16, 2025	Booth Bruce	Director	Sell	286,369	$32.30	$9.25M0.6% OS	0
Oct 15, 2025	Cloonan Michael	President & CEO	Sell	25,200	$31.28	$788.2K	0
Oct 10, 2025	Booth Bruce	Director	Sell	194,932	$30.47	$5.94M	0
Oct 3, 2025	Booth Bruce	Director	Sell	49,546	$29.99	$1.49M	0
Sep 29, 2025	Booth Bruce	Director	Sell	78,693	$30.08	$2.37M	0
Sep 26, 2025	Cloonan Michael	President & CEO	Sell	25,000	$29.11	$727.8K	0
Sep 4, 2025	Fitzpatrick Jennifer	Chief Legal Officer	Sell	10,250	$23.12	$237.0K	0
Aug 29, 2025	Ridloff Elena	CFO & Head of Corp. Dev.	Sell	9,584	$25.09	$240.4K	0
Aug 26, 2025	Ridloff Elena	CFO & Head of Corp. Dev.	Sell	23,416	$25.70	$601.9K	0
Aug 26, 2025	Cloonan Michael	President & CEO	Sell	25,000	$24.97	$624.4K	0
Aug 20, 2025	Cloonan Michael	President & CEO	Sell	25,000	$22.75	$568.8K	0
Aug 19, 2025	Ridloff Elena	CFO & Head of Corp. Dev.	Sell	52,000	$21.62	$1.12M	0
Feb 12, 2025	TPG GP A, LLC	10% Owner	Buy	1,125,000	$18.00	$20.25M2.5% OS	6,684,962
Feb 10, 2025	RA CAPITAL MANAGEMENT, L.P.		Buy	1,125,000	$18.00	$20.25M2.5% OS	6,923,365
Feb 10, 2025	ORBIMED ADVISORS LLC	Director	Buy	550,000	$18.00	$9.90M1.2% OS	3,704,959
Feb 10, 2025	Booth Bruce		Buy	60,000	$18.00	$1.08M	807,727

SION Insider Buying Activity

The following table shows recent insider purchases of Sionna Therapeutics, Inc. (SION) stock reported via SEC Form 4 filings.

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Feb 12, 2025	TPG GP A, LLC	10% Owner	Buy	1,125,000	$18.00	$20.25M2.5% OS	6,684,962
Feb 10, 2025	RA CAPITAL MANAGEMENT, L.P.		Buy	1,125,000	$18.00	$20.25M2.5% OS	6,923,365
Feb 10, 2025	ORBIMED ADVISORS LLC	Director	Buy	550,000	$18.00	$9.90M1.2% OS	3,704,959
Feb 10, 2025	Booth Bruce		Buy	60,000	$18.00	$1.08M	807,727

SION Insider Selling Activity

The following table shows recent insider sales of Sionna Therapeutics, Inc. (SION) stock reported via SEC Form 4 filings.

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
May 29, 2026	ORBIMED ADVISORS LLC	director	Sell	101	$44.49	$4.5K	2,671,721
May 29, 2026	Thompson Peter A.	director	Sell	101	$44.49	$4.5K	2,671,721
May 11, 2026	ORBIMED ADVISORS LLC	director	Sell	292,952	$45.62	$13.36M0.7% OS	2,916,228
May 11, 2026	Thompson Peter A.	director	Sell	292,952	$45.62	$13.36M0.7% OS	2,916,228
Apr 21, 2026	Thompson Peter A.	director	Sell	55,345	$44.67	$2.47M	2,967,722
Apr 21, 2026	ORBIMED ADVISORS LLC	director	Sell	55,345	$44.67	$2.47M	2,967,722
Apr 16, 2026	ORBIMED ADVISORS LLC	director	Sell	510,583	$44.94	$22.95M1.1% OS	3,482,888
Apr 16, 2026	Thompson Peter A.	director	Sell	510,583	$44.94	$22.95M1.1% OS	3,482,888
Mar 6, 2026	Fitzpatrick Jennifer	officer: Chief Legal Officer	Sell	10,250	$33.86	$347.0K	0Exit
Feb 4, 2026	ORBIMED ADVISORS LLC	director	Sell	30,953	$44.58	$1.38M	3,559,765
Feb 2, 2026	Thompson Peter A.	Director	Sell	30,953	$44.58	$1.38M	0
Dec 24, 2025	Thompson Peter A.	Director	Sell	33,356	$44.55	$1.49M	0
Dec 17, 2025	Thompson Peter A.	Director	Sell	1,875	$44.49	$83.4K	0
Dec 5, 2025	Fitzpatrick Jennifer	Chief Legal Officer	Sell	10,250	$40.52	$415.3K	0
Nov 24, 2025	Thompson Peter A.	Director	Sell	108,073	$44.55	$4.81M	0
Oct 21, 2025	Cloonan Michael	President & CEO	Sell	99,800	$36.26	$3.62M	0
Oct 21, 2025	Booth Bruce	Director	Sell	88,878	$34.22	$3.04M	0
Oct 16, 2025	Booth Bruce	Director	Sell	286,369	$32.30	$9.25M0.6% OS	0
Oct 15, 2025	Cloonan Michael	President & CEO	Sell	25,200	$31.28	$788.2K	0
Oct 10, 2025	Booth Bruce	Director	Sell	194,932	$30.47	$5.94M	0
Oct 3, 2025	Booth Bruce	Director	Sell	49,546	$29.99	$1.49M	0
Sep 29, 2025	Booth Bruce	Director	Sell	78,693	$30.08	$2.37M	0
Sep 26, 2025	Cloonan Michael	President & CEO	Sell	25,000	$29.11	$727.8K	0
Sep 4, 2025	Fitzpatrick Jennifer	Chief Legal Officer	Sell	10,250	$23.12	$237.0K	0
Aug 29, 2025	Ridloff Elena	CFO & Head of Corp. Dev.	Sell	9,584	$25.09	$240.4K	0
Aug 26, 2025	Ridloff Elena	CFO & Head of Corp. Dev.	Sell	23,416	$25.70	$601.9K	0
Aug 26, 2025	Cloonan Michael	President & CEO	Sell	25,000	$24.97	$624.4K	0
Aug 20, 2025	Cloonan Michael	President & CEO	Sell	25,000	$22.75	$568.8K	0
Aug 19, 2025	Ridloff Elena	CFO & Head of Corp. Dev.	Sell	52,000	$21.62	$1.12M	0