ORBIMED ADVISORS LLC

SION

ORBIMED ADVISORS LLC serves as director, 10 percent owner: at Sionna Therapeutics, Inc. (SION). This page tracks their complete SEC Form 4 insider trading history including stock purchases and sales.

Total Buys

16 trades

$61.81M

Total Sells

31 trades

$98.83M

Net Position

Net Seller

$37.02M

Companies Traded

PRLD, SION, ACET, XTNT

Active Period

Mar 2021 – Apr 2026

47 total trades

Most Recent

Buy PRLD

Apr 23, 2026 · $12.50M

ORBIMED ADVISORS LLC's Insider Trading at Sionna Therapeutics, Inc. (SION)

Buys

1 · $9.90M

Sells

3 · $26.80M

Total Shares Bought

550,000

Total Shares Sold

596,881

SION Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Apr 21, 2026	Sell	55,345	$44.67	$2.47M	2,967,722
Apr 16, 2026	Sell	510,583	$44.94	$22.95M	3,482,888
Feb 4, 2026	Sell	30,953	$44.58	$1.38M	3,559,765
Feb 10, 2025	Buy	550,000	$18.00	$9.90M	3,704,959

ORBIMED ADVISORS LLC's Insider Trading at Xtant Medical Holdings, Inc. (XTNT)

Buys

0 · $0.00

Sells

1 · $30.71M

Total Shares Bought

Total Shares Sold

73,114,592

XTNT Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Apr 14, 2025	Sell	73,114,592	$0.42	$30.71M	0

ORBIMED ADVISORS LLC's Insider Trading at Prelude Therapeutics Incorporated (PRLD)

Buys

2 · $17.50M

Sells

0 · $0.00

Total Shares Bought

3,684,880

Total Shares Sold

PRLD Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Apr 23, 2026	Buy	2,815,315	$4.44	$12.50M	11,808,945
May 24, 2023	Buy	869,565	$5.75	$5.00M	10,119,756

ORBIMED ADVISORS LLC's Insider Trading at MBX Biosciences, Inc. Common Stock (MBX)

Buys

1 · $12.00M

Sells

0 · $0.00

Total Shares Bought

750,000

Total Shares Sold

MBX Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Sep 17, 2024	Buy	750,000	$16.00	$12.00M	3,158,428

ORBIMED ADVISORS LLC's Insider Trading at ORIC Pharmaceuticals, Inc. (ORIC)

Buys

0 · $0.00

Sells

3 · $11.88M

Total Shares Bought

Total Shares Sold

416,782

ORIC Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Mar 26, 2021	Sell	112,298	$24.53	$2.75M	2,395,334
Mar 18, 2021	Sell	66,202	$27.95	$1.85M	2,486,082
Mar 15, 2021	Sell	238,282	$30.54	$7.28M	2,707,166

ORBIMED ADVISORS LLC's Insider Trading at PMV Pharmaceuticals, Inc. (PMVP)

Buys

0 · $0.00

Sells

3 · $10.88M

Total Shares Bought

Total Shares Sold

588,539

PMVP Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Nov 24, 2023	Sell	87,786	$2.23	$195.8K	0
May 31, 2022	Sell	26,253	$15.93	$418.2K	87,786
Mar 31, 2022	Sell	474,500	$21.63	$10.26M	109,500

ORBIMED ADVISORS LLC's Insider Trading at Terns Pharmaceuticals, Inc. (TERN)

Buys

2 · $9.93M

Sells

0 · $0.00

Total Shares Bought

3,827,931

Total Shares Sold

TERN Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Dec 28, 2022	Buy	137,931	$7.25	$1.00M	4,882,854
Aug 18, 2022	Buy	3,690,000	$2.42	$8.93M	4,744,923

ORBIMED ADVISORS LLC's Insider Trading at Disc Medicine, Inc. (IRON)

Buys

0 · $0.00

Sells

2 · $8.00M

Total Shares Bought

Total Shares Sold

135,824

IRON Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Dec 20, 2023	Sell	1,724	$59.24	$102.1K	0
Dec 14, 2023	Sell	134,100	$58.89	$7.90M	1,182,425

ORBIMED ADVISORS LLC's Insider Trading at Passage Bio, Inc. (PASG)

Buys

5 · $5.76M

Sells

7 · $687.7K

Total Shares Bought

2,404,977

Total Shares Sold

999,374

PASG Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Jan 14, 2025	Sell	223,219	$0.64	$142.2K	7,131,636
Jan 8, 2025	Sell	147,024	$0.70	$103.3K	7,385,388
Dec 26, 2024	Sell	230,321	$0.60	$138.2K	7,404,869
Dec 11, 2024	Sell	62,276	$0.83	$52.0K	7,643,285
Dec 6, 2024	Sell	97,103	$0.80	$77.3K	7,718,369
Sep 23, 2024	Sell	39,300	$0.71	$27.9K	7,794,569
Sep 18, 2024	Sell	200,131	$0.73	$146.7K	7,970,900
Jun 29, 2023	Buy	1,192,577	$0.84	$1.00M	8,034,000
May 5, 2022	Buy	525,000	$1.94	$1.02M	6,841,423
Jan 24, 2022	Buy	369,100	$5.42	$2.00M	6,634,723
Jan 20, 2022	Buy	168,300	$5.38	$905.2K	6,265,623
Jan 13, 2022	Buy	150,000	$5.61	$841.1K	6,097,323

ORBIMED ADVISORS LLC's Insider Trading at TELA Bio, Inc. (TELA)

Buys

0 · $0.00

Sells

2 · $3.81M

Total Shares Bought

Total Shares Sold

620,300

TELA Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Jul 2, 2024	Sell	428,300	$4.72	$2.02M	2,457,542
Apr 21, 2023	Sell	192,000	$9.34	$1.79M	2,891,542

ORBIMED ADVISORS LLC's Insider Trading at ARS Pharmaceuticals, Inc. (SPRY)

Buys

1 · $3.10M

Sells

0 · $0.00

Total Shares Bought

500,000

Total Shares Sold

SPRY Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Aug 31, 2023	Buy	500,000	$6.20	$3.10M	8,019,187

ORBIMED ADVISORS LLC's Insider Trading at Janux Therapeutics, Inc. (JANX)

Buys

0 · $0.00

Sells

2 · $3.09M

Total Shares Bought

Total Shares Sold

159,800

JANX Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Dec 30, 2021	Sell	40,400	$20.30	$820.1K	2,258,566
Dec 23, 2021	Sell	119,400	$19.00	$2.27M	2,295,266

ORBIMED ADVISORS LLC's Insider Trading at Galecto, Inc. (GLTO)

Buys

0 · $0.00

Sells

7 · $2.30M

Total Shares Bought

Total Shares Sold

1,504,628

GLTO Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Aug 17, 2023	Sell	822,680	$0.75	$617.0K	1,510,375
Aug 2, 2023	Sell	209,400	$3.00	$628.2K	2,105,909
Jul 27, 2023	Sell	39,200	$2.92	$114.5K	2,258,987
Jul 17, 2023	Sell	194,700	$2.40	$467.3K	2,285,687
Apr 17, 2023	Sell	68,481	$1.87	$128.3K	2,454,775
Apr 12, 2023	Sell	67,537	$1.80	$121.4K	2,500,582
Apr 7, 2023	Sell	102,630	$2.16	$222.0K	2,516,599

ORBIMED ADVISORS LLC's Insider Trading at Compass Therapeutics, Inc. (CMPX)

Buys

2 · $1.49M

Sells

0 · $0.00

Total Shares Bought

527,359

Total Shares Sold

CMPX Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Nov 10, 2022	Buy	402,000	$3.21	$1.29M	15,219,994
May 10, 2022	Buy	125,359	$1.57	$197.3K	14,625,478

ORBIMED ADVISORS LLC's Insider Trading at ImageneBio Inc (IMA)

Buys

1 · $1.13M

Sells

0 · $0.00

Total Shares Bought

252,225

Total Shares Sold

IMA Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Jun 24, 2022	Buy	252,225	$4.47	$1.13M	2,098,097

ORBIMED ADVISORS LLC's Insider Trading at Edgewise Therapeutics, Inc. (EWTX)

Buys

1 · $995.0K

Sells

0 · $0.00

Total Shares Bought

138,000

Total Shares Sold

EWTX Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
May 20, 2022	Buy	138,000	$7.21	$995.0K	13,497,456

ORBIMED ADVISORS LLC's Insider Trading at Adicet Bio, Inc. (ACET)

Buys

0 · $0.00

Sells

1 · $674.8K

Total Shares Bought

Total Shares Sold

104,658

ACET Price Chart

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Date	Type	Shares	Avg Price	Value	Shares After
Apr 9, 2026	Sell	104,658	$6.45	$674.8K	34,923

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