BAKER BROS. ADVISORS LP

MDGL

BAKER BROS. ADVISORS LP serves as director, 10 percent owner: at Madrigal Pharmaceuticals, Inc. (MDGL). This page tracks their complete SEC Form 4 insider trading history including stock purchases and sales.

Total Buys

35 trades

$1.40B

Total Sells

0 trades

$0.00

Net Position

Net Buyer

$1.40B

Companies Traded

PRLD, KYMR, KALA, TRDA

Active Period

Jun 2021 – Apr 2026

35 total trades

Most Recent

Buy PRLD

Apr 22, 2026 · $225.23

BAKER BROS. ADVISORS LP's Insider Trading at Madrigal Pharmaceuticals, Inc. (MDGL)

Buys

5 · $602.75M

Sells

0 · $0.00

Total Shares Bought

3,130,475

Total Shares Sold

MDGL Price Chart

Loading chart...

Date	Type	Shares	Avg Price	Value	Shares After
Mar 25, 2024	Buy	1,057,692	$260.00	$275.00M	2,493,602
Dec 14, 2023	Buy	136,370	$220.47	$30.07M	1,793,403
Nov 21, 2023	Buy	131,429	$183.18	$24.08M	1,667,104
Nov 15, 2023	Buy	156,886	$150.50	$23.61M	1,545,775
Oct 5, 2023	Buy	1,648,098	$151.69	$250.00M	1,522,651

BAKER BROS. ADVISORS LP's Insider Trading at Incyte Corporation (INCY)

Buys

4 · $286.35M

Sells

0 · $0.00

Total Shares Bought

4,108,777

Total Shares Sold

INCY Price Chart

Loading chart...

Date	Type	Shares	Avg Price	Value	Shares After
Mar 10, 2022	Buy	389,080	$72.24	$28.11M	33,419,056
Feb 22, 2022	Buy	525,804	$67.96	$35.73M	33,039,604
Feb 14, 2022	Buy	1,598,374	$66.91	$106.95M	32,531,488
Dec 17, 2021	Buy	1,595,519	$72.43	$115.56M	30,932,696

BAKER BROS. ADVISORS LP's Insider Trading at Kymera Therapeutics, Inc. (KYMR)

Buys

3 · $201.34M

Sells

0 · $0.00

Total Shares Bought

2,661,314

Total Shares Sold

KYMR Price Chart

Loading chart...

Date	Type	Shares	Avg Price	Value	Shares After
Dec 11, 2025	Buy	2,005,813	$86.00	$172.50M	7,955,916
Jun 30, 2025	Buy	655,500	$44.00	$28.84M	6,117,295
Aug 22, 2024	Buy	1	$46.41	$46.41	5,516,986

BAKER BROS. ADVISORS LP's Insider Trading at Kodiak Sciences Inc. (KOD)

Buys

12 · $137.56M

Sells

0 · $0.00

Total Shares Bought

3,280,555

Total Shares Sold

KOD Price Chart

Loading chart...

Date	Type	Shares	Avg Price	Value	Shares After
Jun 6, 2022	Buy	572,349	$7.77	$4.45M	15,967,504
May 27, 2022	Buy	350,406	$6.75	$2.36M	15,455,507
May 18, 2022	Buy	456,690	$5.91	$2.70M	15,142,074
Feb 17, 2022	Buy	400,965	$54.45	$21.83M	14,734,965
Jan 31, 2022	Buy	347,665	$52.02	$18.08M	14,364,512
Jan 25, 2022	Buy	501,111	$57.49	$28.81M	14,027,837
Oct 1, 2021	Buy	86,932	$95.83	$8.33M	13,526,726
Sep 17, 2021	Buy	31,838	$94.39	$3.01M	13,300,993
Sep 9, 2021	Buy	57,501	$93.31	$5.37M	13,269,155
Aug 19, 2021	Buy	114,396	$87.50	$10.01M	13,211,654
Aug 13, 2021	Buy	102,773	$87.19	$8.96M	13,097,258
Jun 30, 2021	Buy	257,929	$91.72	$23.66M	12,994,485

BAKER BROS. ADVISORS LP's Insider Trading at TScan Therapeutics, Inc. (TCRX)

Buys

3 · $92.93M

Sells

0 · $0.00

Total Shares Bought

12,462,211

Total Shares Sold

TCRX Price Chart

Loading chart...

Date	Type	Shares	Avg Price	Value	Shares After
Apr 23, 2024	Buy	9,677,419	$7.13	$69.00M	43,158,740
May 12, 2022	Buy	1,359,792	$1.88	$2.56M	2,528,583
Jul 22, 2021	Buy	1,425,000	$15.00	$21.38M	1,320,302

BAKER BROS. ADVISORS LP's Insider Trading at Entrada Therapeutics, Inc. (TRDA)

Buys

4 · $50.97M

Sells

0 · $0.00

Total Shares Bought

3,528,403

Total Shares Sold

TRDA Price Chart

Loading chart...

Date	Type	Shares	Avg Price	Value	Shares After
Jun 26, 2024	Buy	3,367,003	$14.85	$50.00M	3,081,303
Jun 6, 2022	Buy	40,947	$6.37	$260.8K	4,501,658
May 24, 2022	Buy	48,509	$5.82	$282.4K	4,465,029
May 18, 2022	Buy	71,944	$5.99	$430.7K	4,421,689

BAKER BROS. ADVISORS LP's Insider Trading at ACADIA Pharmaceuticals Inc. (ACAD)

Buys

1 · $22.71M

Sells

0 · $0.00

Total Shares Bought

896,522

Total Shares Sold

ACAD Price Chart

Loading chart...

Date	Type	Shares	Avg Price	Value	Shares After
May 24, 2023	Buy	896,522	$25.33	$22.71M	39,317,672

BAKER BROS. ADVISORS LP's Insider Trading at KALA BIO, Inc. (KALA)

Buys

1 · $2.00M

Sells

0 · $0.00

Total Shares Bought

310,559

Total Shares Sold

KALA Price Chart

Loading chart...

Date	Type	Shares	Avg Price	Value	Shares After
Dec 31, 2024	Buy	310,559	$6.44	$2.00M	1,083,398

BAKER BROS. ADVISORS LP's Insider Trading at Neurogene Inc. (NGNE)

Buys

1 · $1.46M

Sells

0 · $0.00

Total Shares Bought

2,285,342

Total Shares Sold

NGNE Price Chart

Loading chart...

Date	Type	Shares	Avg Price	Value	Shares After
Aug 17, 2023	Buy	2,285,342	$0.64	$1.46M	5,612,949

BAKER BROS. ADVISORS LP's Insider Trading at Prelude Therapeutics Incorporated (PRLD)

Buys

1 · $225.23

Sells

0 · $0.00

Total Shares Bought

2,252,252

Total Shares Sold

PRLD Price Chart

Loading chart...

Date	Type	Shares	Avg Price	Value	Shares After
Apr 22, 2026	Buy	2,252,252	$0.00	$225.23	20,105,994

Related Insiders

Jeremy G Chadwick

officer: Chief Operating Officer

KYMRSell · Apr 24, 2026

Bruce Booth

director

KYMRSell · Apr 24, 2026

David P Bonita

director, 10 percent owner:

PRLDBuy · Apr 23, 2026

ORBIMED ADVISORS LLC

director, 10 percent owner:

PRLDBuy · Apr 23, 2026

Noah Goodman

officer: Chief Business Officer

KYMRSell · Apr 16, 2026

Elena Ridloff

director

KYMRSell · Apr 1, 2026

Pamela Esposito

Director

KYMRSell · Mar 20, 2026

Nello Mainolfi

director, officer: Chief Executive Officer

KYMRSell · Feb 25, 2026

Explore More Insider Trading Data

MDGL Insider Trading Activity

View all insider trades at Madrigal Pharmaceuticals, Inc.

Healthcare Sector Insider Trades

See insider activity across healthcare stocks

Latest Insider Buys

Most recent insider purchases across all stocks

CEO Stock Purchases

Track CEO buying activity