SEPN

Septerna, Inc.$23.12-1.17 (-4.82%)

Prev Close$24.29·MCap$1.12B·P/E—·Vol221.5K·Yield—

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Buys (12M)

$0.00

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Sells (12M)

$392.3K

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Net Activity

Net Seller

$392.3K

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Active Insiders

last 12 mo

Over the past 12 months, insider activity at Septerna, Inc. (SEPN) has been exclusively selling, with 0 insider purchases totaling $0.00 and 4 insider sales totaling $392.3K. The most recent insider transaction was by Bhatt Elizabeth (officer: President and COO), who sold $97.3K worth of shares on Apr 17, 2026. Septerna, Inc. operates in the Healthcare sector, within the Biotechnology industry, with a market cap of $1.12B.

SEPN Insider Trading Activity

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Apr 17, 2026	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$24.34	$97.3K	175,636
Feb 20, 2026	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$28.97	$115.9K	176,009
Feb 18, 2026	Bhatt Elizabeth	President and COO	Sell	4,000	$28.97	$115.9K	0
Nov 13, 2025	Long Daniel D.	SVP, Drug Discovery	Sell	3,501	$18.06	$63.2K	92,911
Mar 10, 2025	Ezekowitz Alan		Buy	13,319	$6.93	$92.3K	117,420
Mar 6, 2025	Ezekowitz Alan		Buy	86,681	$5.95	$515.9K	104,101+498%
Feb 27, 2025	Finer Jeffrey	CEO and President	Buy	17,000	$5.70	$97.0K	771,907
Feb 27, 2025	Labrucherie Gil M	Chief Financial Officer	Buy	10,000	$5.69	$56.9K	40,000+33%
Feb 26, 2025	Third Rock Ventures VI, L.P.		Buy	18,861	$6.00	$113.1K	4,211,659
Feb 24, 2025	Third Rock Ventures VI, L.P.		Buy	1,040,342	$5.93	$6.17M2.3% OS	4,192,798+33%
Feb 21, 2025	Labrucherie Gil M	Chief Financial Officer	Buy	30,000	$5.74	$172.3K	30,000
Oct 30, 2024	RA CAPITAL MANAGEMENT, L.P.		Buy	4,170,000	$18.00	$75.06M9.3% OS	5,523,915+308%
Oct 28, 2024	Third Rock Ventures V, L.P.		Buy	650,000	$18.00	$11.70M1.4% OS	6,215,591

SEPN Insider Buying Activity

The following table shows recent insider purchases of Septerna, Inc. (SEPN) stock reported via SEC Form 4 filings.

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Mar 10, 2025	Ezekowitz Alan		Buy	13,319	$6.93	$92.3K	117,420
Mar 6, 2025	Ezekowitz Alan		Buy	86,681	$5.95	$515.9K	104,101+498%
Feb 27, 2025	Finer Jeffrey	CEO and President	Buy	17,000	$5.70	$97.0K	771,907
Feb 27, 2025	Labrucherie Gil M	Chief Financial Officer	Buy	10,000	$5.69	$56.9K	40,000+33%
Feb 26, 2025	Third Rock Ventures VI, L.P.		Buy	18,861	$6.00	$113.1K	4,211,659
Feb 24, 2025	Third Rock Ventures VI, L.P.		Buy	1,040,342	$5.93	$6.17M2.3% OS	4,192,798+33%
Feb 21, 2025	Labrucherie Gil M	Chief Financial Officer	Buy	30,000	$5.74	$172.3K	30,000
Oct 30, 2024	RA CAPITAL MANAGEMENT, L.P.		Buy	4,170,000	$18.00	$75.06M9.3% OS	5,523,915+308%
Oct 28, 2024	Third Rock Ventures V, L.P.		Buy	650,000	$18.00	$11.70M1.4% OS	6,215,591

SEPN Insider Selling Activity

The following table shows recent insider sales of Septerna, Inc. (SEPN) stock reported via SEC Form 4 filings.

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Apr 17, 2026	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$24.34	$97.3K	175,636
Feb 20, 2026	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$28.97	$115.9K	176,009
Feb 18, 2026	Bhatt Elizabeth	President and COO	Sell	4,000	$28.97	$115.9K	0
Nov 13, 2025	Long Daniel D.	SVP, Drug Discovery	Sell	3,501	$18.06	$63.2K	92,911