SEPN

Septerna Inc$37.80-1.11 (-2.85%)

Prev Close$38.91·MCap$1.75B·P/E—·Vol160.8K·Yield—

▲

Buys (12M)

$0.00

▼

Sells (12M)

$42.34M

◆

Net Activity

Net Seller

$42.34M

●

Active Insiders

last 12 mo

Over the past 12 months, insider activity at Septerna Inc (SEPN) has been exclusively selling, with 0 insider purchases totaling $0.00 and 15 insider sales totaling $42.34M. The most recent insider transaction was by RA CAPITAL MANAGEMENT, L.P. (director, 10 percent owner: ), who sold $31.73M worth of shares on Aug 14, 2026. Septerna Inc operates in the Healthcare sector, within the Biotechnology industry, with a market cap of $1.75B.

SEPN Insider Trading Activity

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Aug 14, 2026	RA CAPITAL MANAGEMENT, L.P.	director, 10 percent owner:	Sell	746,500	$42.50	$31.73M1.7% OS	725,443-51%
Aug 14, 2026	Third Rock Ventures V, L.P.	10 percent owner	Sell	147,200	$50.27	$7.40M	6,068,532
Aug 13, 2026	Bhatt Elizabeth	officer: President and COO	Sell	25,000	$44.00	$1.10M	174,209
Aug 5, 2026	Long Daniel D.	officer: SVP, Drug Discovery	Sell	3,334	$34.47	$114.9K	98,746
Jul 17, 2026	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$33.99	$136.0K	174,209
Jul 2, 2026	Long Daniel D.	officer: SVP, Drug Discovery	Sell	3,333	$34.36	$114.5K	97,645
Jun 30, 2026	Shaikhly Samira	officer: Chief People Officer	Sell	2,178	$35.18	$76.6K	793-73%
Jun 24, 2026	Long Daniel D.	officer: SVP, Drug Discovery	Sell	15,000	$35.51	$532.6K	103,412
Jun 16, 2026	Shaikhly Samira	officer: Chief People Officer	Sell	6,250	$35.08	$219.2K	793-89%
Jun 3, 2026	Shaikhly Samira	officer: Chief People Officer	Sell	5,935	$28.93	$171.7K	5,028-54%
May 28, 2026	Shaikhly Samira	officer: Chief People Officer	Sell	11,798	$30.06	$354.7K	793-94%
Apr 17, 2026	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$24.34	$97.3K	175,636
Feb 20, 2026	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$28.97	$115.9K	176,009
Feb 18, 2026	Bhatt Elizabeth	President and COO	Sell	4,000	$28.97	$115.9K	0
Nov 13, 2025	Long Daniel D.	SVP, Drug Discovery	Sell	3,501	$18.06	$63.2K	92,911
Mar 10, 2025	Ezekowitz Alan		Buy	13,319	$6.93	$92.3K	117,420
Mar 6, 2025	Ezekowitz Alan		Buy	86,681	$5.95	$515.9K	104,101+498%
Feb 27, 2025	Finer Jeffrey	CEO and President	Buy	17,000	$5.70	$97.0K	771,907
Feb 27, 2025	Labrucherie Gil M	Chief Financial Officer	Buy	10,000	$5.69	$56.9K	40,000+33%
Feb 26, 2025	Third Rock Ventures VI, L.P.		Buy	18,861	$6.00	$113.1K	4,211,659
Feb 24, 2025	Third Rock Ventures VI, L.P.		Buy	1,040,342	$5.93	$6.17M2.3% OS	4,192,798+33%
Feb 21, 2025	Labrucherie Gil M	Chief Financial Officer	Buy	30,000	$5.74	$172.3K	30,000
Oct 30, 2024	RA CAPITAL MANAGEMENT, L.P.		Buy	4,170,000	$18.00	$75.06M9.3% OS	5,523,915+308%
Oct 28, 2024	Third Rock Ventures V, L.P.		Buy	650,000	$18.00	$11.70M1.4% OS	6,215,591

SEPN Insider Buying Activity

The following table shows recent insider purchases of Septerna Inc (SEPN) stock reported via SEC Form 4 filings.

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Mar 10, 2025	Ezekowitz Alan		Buy	13,319	$6.93	$92.3K	117,420
Mar 6, 2025	Ezekowitz Alan		Buy	86,681	$5.95	$515.9K	104,101+498%
Feb 27, 2025	Finer Jeffrey	CEO and President	Buy	17,000	$5.70	$97.0K	771,907
Feb 27, 2025	Labrucherie Gil M	Chief Financial Officer	Buy	10,000	$5.69	$56.9K	40,000+33%
Feb 26, 2025	Third Rock Ventures VI, L.P.		Buy	18,861	$6.00	$113.1K	4,211,659
Feb 24, 2025	Third Rock Ventures VI, L.P.		Buy	1,040,342	$5.93	$6.17M2.3% OS	4,192,798+33%
Feb 21, 2025	Labrucherie Gil M	Chief Financial Officer	Buy	30,000	$5.74	$172.3K	30,000
Oct 30, 2024	RA CAPITAL MANAGEMENT, L.P.		Buy	4,170,000	$18.00	$75.06M9.3% OS	5,523,915+308%
Oct 28, 2024	Third Rock Ventures V, L.P.		Buy	650,000	$18.00	$11.70M1.4% OS	6,215,591

SEPN Insider Selling Activity

The following table shows recent insider sales of Septerna Inc (SEPN) stock reported via SEC Form 4 filings.

Date	Insider	Role	Type	Shares	Avg Price	Value	Shares After
Aug 14, 2026	RA CAPITAL MANAGEMENT, L.P.	director, 10 percent owner:	Sell	746,500	$42.50	$31.73M1.7% OS	725,443-51%
Aug 14, 2026	Third Rock Ventures V, L.P.	10 percent owner	Sell	147,200	$50.27	$7.40M	6,068,532
Aug 13, 2026	Bhatt Elizabeth	officer: President and COO	Sell	25,000	$44.00	$1.10M	174,209
Aug 5, 2026	Long Daniel D.	officer: SVP, Drug Discovery	Sell	3,334	$34.47	$114.9K	98,746
Jul 17, 2026	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$33.99	$136.0K	174,209
Jul 2, 2026	Long Daniel D.	officer: SVP, Drug Discovery	Sell	3,333	$34.36	$114.5K	97,645
Jun 30, 2026	Shaikhly Samira	officer: Chief People Officer	Sell	2,178	$35.18	$76.6K	793-73%
Jun 24, 2026	Long Daniel D.	officer: SVP, Drug Discovery	Sell	15,000	$35.51	$532.6K	103,412
Jun 16, 2026	Shaikhly Samira	officer: Chief People Officer	Sell	6,250	$35.08	$219.2K	793-89%
Jun 3, 2026	Shaikhly Samira	officer: Chief People Officer	Sell	5,935	$28.93	$171.7K	5,028-54%
May 28, 2026	Shaikhly Samira	officer: Chief People Officer	Sell	11,798	$30.06	$354.7K	793-94%
Apr 17, 2026	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$24.34	$97.3K	175,636
Feb 20, 2026	Bhatt Elizabeth	officer: President and COO	Sell	4,000	$28.97	$115.9K	176,009
Feb 18, 2026	Bhatt Elizabeth	President and COO	Sell	4,000	$28.97	$115.9K	0
Nov 13, 2025	Long Daniel D.	SVP, Drug Discovery	Sell	3,501	$18.06	$63.2K	92,911