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Amylyx Pharmaceuticals, Inc.

$13.90-0.47 (-3.30%)

Prev Close

$14.38

Open

$14.50

High

$15.01

Low

$13.78

Volume

554.5K

Market Cap

$1.17B

P/E

Div Yield

Over the past 12 months, insider activity at Amylyx Pharmaceuticals, Inc. (AMLX) has been dominated by selling, with 2 insider purchases totaling $137.8K and 36 insider sales totaling $13.33M. The most recent insider transaction was by Bedrosian Camille L (officer: Chief Medical Officer), who sold $188.4K worth of shares on Mar 4, 2026. Amylyx Pharmaceuticals, Inc. operates in the Healthcare sector, within the Biotechnology industry, with a market cap of $1.17B.

Buys (12M)

2

$137.8K

Sells (12M)

36

$13.33M

Net Activity

Net Seller

$13.19M

Active Insiders

7

last 12 mo

AMLX Price Chart

AMLX Insider Trading Activity

DateInsiderRoleTypeSharesAvg PriceValueShares After
Mar 4, 2026Bedrosian Camille Lofficer: Chief Medical OfficerSell12,922$14.58$188.4K169,295
Mar 4, 2026Cohen Joshua Bdirector, officer: Co-Chief Executive OfficerSell58,564$14.48$848.2K3,334,680
Mar 4, 2026FRATES JAMES Mofficer: Chief Financial OfficerSell15,818$14.52$229.7K165,638
Mar 4, 2026Klee Justin B.director, officer: Co-Chief Executive OfficerSell58,564$14.47$847.5K3,334,620
Mar 4, 2026Mazzariello Ginaofficer: Chief Legal OfficerSell13,688$14.52$198.8K134,430
Feb 25, 2026Mazzariello Ginaofficer: Chief Legal OfficerSell3,419$14.14$48.4K141,274
Feb 4, 2026Cohen Joshua Bdirector, officer: Co-Chief Executive OfficerSell15,500$14.68$227.6K3,363,960
Feb 4, 2026FRATES JAMES Mofficer: Chief Financial OfficerSell3,557$14.65$52.1K173,547
Feb 4, 2026Klee Justin B.director, officer: Co-Chief Executive OfficerSell15,500$14.69$227.6K3,363,900
Feb 4, 2026Mazzariello Ginaofficer: Chief Legal OfficerSell3,448$14.65$50.5K144,693
Feb 2, 2026Cohen Joshua BCo-Chief Executive OfficerSell15,500$14.68$227.6K0
Feb 2, 2026FRATES JAMES MChief Financial OfficerSell3,557$14.65$52.1K0
Feb 2, 2026Klee Justin B.Co-Chief Executive OfficerSell15,500$14.69$227.6K0
Feb 2, 2026Mazzariello GinaChief Legal OfficerSell3,448$14.65$50.5K0
Jan 20, 2026Cohen Joshua Bdirector, officer: Co-Chief Executive OfficerSell138,167$13.59$1.88M3,379,460
Jan 20, 2026Klee Justin B.director, officer: Co-Chief Executive OfficerSell138,188$13.59$1.88M3,379,400
Jan 15, 2026Cohen Joshua BCo-Chief Executive OfficerSell138,167$13.59$1.88M0
Jan 15, 2026Klee Justin B.Co-Chief Executive OfficerSell138,188$13.59$1.88M0
Jan 8, 2026Cohen Joshua Bdirector, officer: Co-Chief Executive OfficerSell7,715$11.09$85.6K3,317,630
Jan 8, 2026FRATES JAMES Mofficer: Chief Financial OfficerSell3,326$11.11$37.0K177,104
Jan 8, 2026Klee Justin B.director, officer: Co-Chief Executive OfficerSell7,715$11.09$85.6K3,317,590
Jan 6, 2026Cohen Joshua BCo-Chief Executive OfficerSell7,715$11.09$85.6K0
Jan 6, 2026FRATES JAMES MChief Financial OfficerSell3,326$11.11$37.0K0
Jan 6, 2026Klee Justin B.Co-Chief Executive OfficerSell7,715$11.09$85.6K0
Dec 23, 2025Firestone KarenDirectorBuy8,100$12.45$100.8K0
Dec 1, 2025Bedrosian Camille LChief Medical OfficerSell6,580$14.35$94.4K0
Sep 30, 2025Bedrosian Camille LChief Medical OfficerSell12,039$14.58$175.5K0
Sep 30, 2025Cohen Joshua BCo-Chief Executive OfficerSell29,933$14.35$429.5K0
Sep 30, 2025FRATES JAMES MChief Financial OfficerSell10,558$14.65$154.7K0
Sep 30, 2025Klee Justin B.Co-Chief Executive OfficerSell29,975$14.38$431.0K0
Sep 30, 2025Mazzariello GinaChief Legal OfficerSell8,828$14.58$128.7K0
Aug 12, 2025Mazzariello GinaChief Legal OfficerSell30,000$8.20$246.1K0
Mar 31, 2025Bedrosian Camille LChief Medical OfficerSell12,425$3.47$43.1K0
Mar 31, 2025Cohen Joshua BCo-Chief Executive OfficerSell21,490$3.47$74.5K0
Mar 31, 2025FRATES JAMES MChief Financial OfficerSell10,896$3.47$37.8K0
Mar 31, 2025Klee Justin B.Co-Chief Executive OfficerSell21,490$3.46$74.5K0
Mar 31, 2025Mazzariello GinaChief Legal OfficerSell9,192$3.48$32.0K0
Mar 20, 2025Zeiher Bernhardt GDirectorBuy10,000$3.70$37.0K0
Mar 3, 2025Cohen Joshua BCo-Chief Executive OfficerSell4,595$3.17$14.5K0
Mar 3, 2025Klee Justin B.Co-Chief Executive OfficerSell4,595$3.15$14.5K0
Mar 3, 2025Mazzariello GinaChief Legal OfficerSell1,611$3.12$5.0K0
Feb 24, 2025Mazzariello GinaChief Legal OfficerSell4,169$3.15$13.1K0
Feb 3, 2025Cohen Joshua BCo-Chief Executive OfficerSell11,851$3.47$41.1K0
Feb 3, 2025Klee Justin B.Co-Chief Executive OfficerSell11,855$3.47$41.1K0
Feb 3, 2025Mazzariello GinaChief Legal OfficerSell3,678$3.49$12.8K0
Jan 6, 2025Cohen Joshua BCo-Chief Executive OfficerSell7,471$4.05$30.2K0
Jan 6, 2025Klee Justin B.Co-Chief Executive OfficerSell7,471$4.04$30.2K0
Dec 2, 2024Bedrosian Camille LChief Medical OfficerSell5,421$5.54$30.0K0
Sep 30, 2024Bedrosian Camille LChief Medical OfficerSell11,442$3.20$36.6K0
Sep 30, 2024Cohen Joshua BCo-Chief Executive OfficerSell18,589$3.20$59.4K0
Sep 30, 2024Klee Justin B.Co-Chief Executive OfficerSell18,589$3.20$59.4K0
Sep 30, 2024Mazzariello GinaChief Legal OfficerSell8,709$3.20$27.8K0
Sep 12, 2024FRATES JAMES MChief Financial OfficerBuy40,000$2.53$101.4K0
Sep 5, 2024Firestone KarenDirectorBuy50,000$2.13$106.6K0
Sep 3, 2024MILNE GEORGE M JRDirectorBuy100,000$2.20$219.8K0
May 15, 2024Mazzariello GinaChief Legal OfficerSell10,455$1.88$19.7K0
May 14, 2024Quimi DaphneDirectorBuy5,000$1.89$9.4K0
Mar 5, 2024Cohen Joshua BCo-Chief Executive OfficerSell4,135$18.73$77.4K0
Mar 5, 2024FRATES JAMES MChief Financial OfficerSell1,792$18.73$33.6K0
Mar 5, 2024Klee Justin B.Co-Chief Executive OfficerSell4,135$18.73$77.4K0
Mar 5, 2024Mazzariello GinaChief Legal OfficerSell1,540$18.73$28.8K0
Feb 23, 2024Mazzariello GinaChief Legal OfficerSell2,838$18.76$53.2K0
Jan 9, 2024Cohen Joshua BCo-Chief Executive OfficerSell5,841$16.33$95.4K0
Jan 9, 2024FRATES JAMES MChief Financial OfficerSell2,716$16.33$44.3K0
Jan 9, 2024Klee Justin B.Co-Chief Executive OfficerSell5,841$16.33$95.4K0
Jan 9, 2024Yeramian Patrick DChief Medical OfficerSell2,812$16.33$45.9K0
Dec 15, 2023Firestone KarenDirectorBuy4,000$14.97$59.9K0
Aug 15, 2023Mazzariello GinaChief Legal OfficerSell6,164$20.88$128.7K0
May 16, 2023FRATES JAMES MChief Financial OfficerSell32,500$26.94$875.5K0
May 15, 2023Yeramian Patrick DChief Medical OfficerSell11,965$29.03$347.4K0
Apr 17, 2023Yeramian Patrick DChief Medical OfficerSell49,579$30.54$1.51M0
Mar 16, 2023Cohen Joshua BCo-Chief Executive OfficerSell100,000$31.86$3.19M0
Mar 16, 2023Firestone KarenDirectorBuy1,000$31.99$32.0K0
Mar 16, 2023FRATES JAMES MChief Financial OfficerSell32,500$31.89$1.04M0
Mar 16, 2023Klee Justin B.Co-Chief Executive OfficerSell100,000$31.86$3.19M0
Mar 16, 2023MILNE GEORGE M JRDirectorSell35,000$31.89$1.12M0
Mar 16, 2023Yeramian Patrick DChief Medical OfficerSell54,627$31.87$1.74M0
Feb 24, 2023Mazzariello GinaChief Legal OfficerSell3,586$34.49$123.7K0
Jan 6, 2023Cohen Joshua BCo-Chief Executive OfficerSell5,968$36.30$216.6K0
Jan 6, 2023FRATES JAMES MChief Financial OfficerSell2,658$36.30$96.5K0
Jan 6, 2023Klee Justin B.Co-Chief Executive OfficerSell5,968$36.30$216.6K0
Jan 6, 2023Olinger MargaretChief Commercial OfficerSell2,403$36.30$87.2K0
Jan 6, 2023Yeramian Patrick DChief Medical OfficerSell2,034$36.30$73.8K0
Jul 6, 2022ALS Invest 1 B.V.10% OwnerSell60,609$20.70$1.25M0
Jan 6, 2022Cheng IsaacDirectorBuy6,578$19.00$125.0K0
Jan 6, 2022FONTEYNE PAUL R.DirectorBuy3,947$19.00$75.0K0
Jan 6, 2022MILNE GEORGE M JRDirectorBuy26,315$19.00$500.0K0
Jan 6, 2022Olinger MargaretChief Commercial OfficerBuy6,842$19.00$130.0K0

AMLX Insider Buying Activity

The following table shows recent insider purchases of Amylyx Pharmaceuticals, Inc. (AMLX) stock reported via SEC Form 4 filings.

DateInsiderRoleTypeSharesAvg PriceValueShares After
Dec 23, 2025Firestone KarenDirectorBuy8,100$12.45$100.8K0
Mar 20, 2025Zeiher Bernhardt GDirectorBuy10,000$3.70$37.0K0
Sep 12, 2024FRATES JAMES MChief Financial OfficerBuy40,000$2.53$101.4K0
Sep 5, 2024Firestone KarenDirectorBuy50,000$2.13$106.6K0
Sep 3, 2024MILNE GEORGE M JRDirectorBuy100,000$2.20$219.8K0
May 14, 2024Quimi DaphneDirectorBuy5,000$1.89$9.4K0
Dec 15, 2023Firestone KarenDirectorBuy4,000$14.97$59.9K0
Mar 16, 2023Firestone KarenDirectorBuy1,000$31.99$32.0K0
Jan 6, 2022Cheng IsaacDirectorBuy6,578$19.00$125.0K0
Jan 6, 2022FONTEYNE PAUL R.DirectorBuy3,947$19.00$75.0K0
Jan 6, 2022MILNE GEORGE M JRDirectorBuy26,315$19.00$500.0K0
Jan 6, 2022Olinger MargaretChief Commercial OfficerBuy6,842$19.00$130.0K0

AMLX Insider Selling Activity

The following table shows recent insider sales of Amylyx Pharmaceuticals, Inc. (AMLX) stock reported via SEC Form 4 filings.

DateInsiderRoleTypeSharesAvg PriceValueShares After
Mar 4, 2026Bedrosian Camille Lofficer: Chief Medical OfficerSell12,922$14.58$188.4K169,295
Mar 4, 2026Cohen Joshua Bdirector, officer: Co-Chief Executive OfficerSell58,564$14.48$848.2K3,334,680
Mar 4, 2026FRATES JAMES Mofficer: Chief Financial OfficerSell15,818$14.52$229.7K165,638
Mar 4, 2026Klee Justin B.director, officer: Co-Chief Executive OfficerSell58,564$14.47$847.5K3,334,620
Mar 4, 2026Mazzariello Ginaofficer: Chief Legal OfficerSell13,688$14.52$198.8K134,430
Feb 25, 2026Mazzariello Ginaofficer: Chief Legal OfficerSell3,419$14.14$48.4K141,274
Feb 4, 2026Cohen Joshua Bdirector, officer: Co-Chief Executive OfficerSell15,500$14.68$227.6K3,363,960
Feb 4, 2026FRATES JAMES Mofficer: Chief Financial OfficerSell3,557$14.65$52.1K173,547
Feb 4, 2026Klee Justin B.director, officer: Co-Chief Executive OfficerSell15,500$14.69$227.6K3,363,900
Feb 4, 2026Mazzariello Ginaofficer: Chief Legal OfficerSell3,448$14.65$50.5K144,693
Feb 2, 2026Cohen Joshua BCo-Chief Executive OfficerSell15,500$14.68$227.6K0
Feb 2, 2026FRATES JAMES MChief Financial OfficerSell3,557$14.65$52.1K0
Feb 2, 2026Klee Justin B.Co-Chief Executive OfficerSell15,500$14.69$227.6K0
Feb 2, 2026Mazzariello GinaChief Legal OfficerSell3,448$14.65$50.5K0
Jan 20, 2026Cohen Joshua Bdirector, officer: Co-Chief Executive OfficerSell138,167$13.59$1.88M3,379,460
Jan 20, 2026Klee Justin B.director, officer: Co-Chief Executive OfficerSell138,188$13.59$1.88M3,379,400
Jan 15, 2026Cohen Joshua BCo-Chief Executive OfficerSell138,167$13.59$1.88M0
Jan 15, 2026Klee Justin B.Co-Chief Executive OfficerSell138,188$13.59$1.88M0
Jan 8, 2026Cohen Joshua Bdirector, officer: Co-Chief Executive OfficerSell7,715$11.09$85.6K3,317,630
Jan 8, 2026FRATES JAMES Mofficer: Chief Financial OfficerSell3,326$11.11$37.0K177,104
Jan 8, 2026Klee Justin B.director, officer: Co-Chief Executive OfficerSell7,715$11.09$85.6K3,317,590
Jan 6, 2026Cohen Joshua BCo-Chief Executive OfficerSell7,715$11.09$85.6K0
Jan 6, 2026FRATES JAMES MChief Financial OfficerSell3,326$11.11$37.0K0
Jan 6, 2026Klee Justin B.Co-Chief Executive OfficerSell7,715$11.09$85.6K0
Dec 1, 2025Bedrosian Camille LChief Medical OfficerSell6,580$14.35$94.4K0
Sep 30, 2025Bedrosian Camille LChief Medical OfficerSell12,039$14.58$175.5K0
Sep 30, 2025Cohen Joshua BCo-Chief Executive OfficerSell29,933$14.35$429.5K0
Sep 30, 2025FRATES JAMES MChief Financial OfficerSell10,558$14.65$154.7K0
Sep 30, 2025Klee Justin B.Co-Chief Executive OfficerSell29,975$14.38$431.0K0
Sep 30, 2025Mazzariello GinaChief Legal OfficerSell8,828$14.58$128.7K0
Aug 12, 2025Mazzariello GinaChief Legal OfficerSell30,000$8.20$246.1K0
Mar 31, 2025Bedrosian Camille LChief Medical OfficerSell12,425$3.47$43.1K0
Mar 31, 2025Cohen Joshua BCo-Chief Executive OfficerSell21,490$3.47$74.5K0
Mar 31, 2025FRATES JAMES MChief Financial OfficerSell10,896$3.47$37.8K0
Mar 31, 2025Klee Justin B.Co-Chief Executive OfficerSell21,490$3.46$74.5K0
Mar 31, 2025Mazzariello GinaChief Legal OfficerSell9,192$3.48$32.0K0
Mar 3, 2025Cohen Joshua BCo-Chief Executive OfficerSell4,595$3.17$14.5K0
Mar 3, 2025Klee Justin B.Co-Chief Executive OfficerSell4,595$3.15$14.5K0
Mar 3, 2025Mazzariello GinaChief Legal OfficerSell1,611$3.12$5.0K0
Feb 24, 2025Mazzariello GinaChief Legal OfficerSell4,169$3.15$13.1K0
Feb 3, 2025Cohen Joshua BCo-Chief Executive OfficerSell11,851$3.47$41.1K0
Feb 3, 2025Klee Justin B.Co-Chief Executive OfficerSell11,855$3.47$41.1K0
Feb 3, 2025Mazzariello GinaChief Legal OfficerSell3,678$3.49$12.8K0
Jan 6, 2025Cohen Joshua BCo-Chief Executive OfficerSell7,471$4.05$30.2K0
Jan 6, 2025Klee Justin B.Co-Chief Executive OfficerSell7,471$4.04$30.2K0
Dec 2, 2024Bedrosian Camille LChief Medical OfficerSell5,421$5.54$30.0K0
Sep 30, 2024Bedrosian Camille LChief Medical OfficerSell11,442$3.20$36.6K0
Sep 30, 2024Cohen Joshua BCo-Chief Executive OfficerSell18,589$3.20$59.4K0
Sep 30, 2024Klee Justin B.Co-Chief Executive OfficerSell18,589$3.20$59.4K0
Sep 30, 2024Mazzariello GinaChief Legal OfficerSell8,709$3.20$27.8K0
May 15, 2024Mazzariello GinaChief Legal OfficerSell10,455$1.88$19.7K0
Mar 5, 2024Cohen Joshua BCo-Chief Executive OfficerSell4,135$18.73$77.4K0
Mar 5, 2024FRATES JAMES MChief Financial OfficerSell1,792$18.73$33.6K0
Mar 5, 2024Klee Justin B.Co-Chief Executive OfficerSell4,135$18.73$77.4K0
Mar 5, 2024Mazzariello GinaChief Legal OfficerSell1,540$18.73$28.8K0
Feb 23, 2024Mazzariello GinaChief Legal OfficerSell2,838$18.76$53.2K0
Jan 9, 2024Cohen Joshua BCo-Chief Executive OfficerSell5,841$16.33$95.4K0
Jan 9, 2024FRATES JAMES MChief Financial OfficerSell2,716$16.33$44.3K0
Jan 9, 2024Klee Justin B.Co-Chief Executive OfficerSell5,841$16.33$95.4K0
Jan 9, 2024Yeramian Patrick DChief Medical OfficerSell2,812$16.33$45.9K0
Aug 15, 2023Mazzariello GinaChief Legal OfficerSell6,164$20.88$128.7K0
May 16, 2023FRATES JAMES MChief Financial OfficerSell32,500$26.94$875.5K0
May 15, 2023Yeramian Patrick DChief Medical OfficerSell11,965$29.03$347.4K0
Apr 17, 2023Yeramian Patrick DChief Medical OfficerSell49,579$30.54$1.51M0
Mar 16, 2023Cohen Joshua BCo-Chief Executive OfficerSell100,000$31.86$3.19M0
Mar 16, 2023FRATES JAMES MChief Financial OfficerSell32,500$31.89$1.04M0
Mar 16, 2023Klee Justin B.Co-Chief Executive OfficerSell100,000$31.86$3.19M0
Mar 16, 2023MILNE GEORGE M JRDirectorSell35,000$31.89$1.12M0
Mar 16, 2023Yeramian Patrick DChief Medical OfficerSell54,627$31.87$1.74M0
Feb 24, 2023Mazzariello GinaChief Legal OfficerSell3,586$34.49$123.7K0
Jan 6, 2023Cohen Joshua BCo-Chief Executive OfficerSell5,968$36.30$216.6K0
Jan 6, 2023FRATES JAMES MChief Financial OfficerSell2,658$36.30$96.5K0
Jan 6, 2023Klee Justin B.Co-Chief Executive OfficerSell5,968$36.30$216.6K0
Jan 6, 2023Olinger MargaretChief Commercial OfficerSell2,403$36.30$87.2K0
Jan 6, 2023Yeramian Patrick DChief Medical OfficerSell2,034$36.30$73.8K0
Jul 6, 2022ALS Invest 1 B.V.10% OwnerSell60,609$20.70$1.25M0

AMLX Insiders

Bedrosian Camille L

officer: Chief Medical Officer

Sold $188.4K
2 tradesLast: Mar 2, 2026
Cohen Joshua B

director, officer: Co-Chief Executive Officer

Sold $3.04M
6 tradesLast: Mar 2, 2026
FRATES JAMES M

officer: Chief Financial Officer

Sold $318.8K
4 tradesLast: Mar 2, 2026
Klee Justin B.

director, officer: Co-Chief Executive Officer

Sold $3.04M
6 tradesLast: Mar 2, 2026
Mazzariello Gina

officer: Chief Legal Officer

Sold $297.6K
4 tradesLast: Mar 2, 2026
Cohen Joshua B

Co-Chief Executive Officer

Sold $6.42M
17 tradesLast: Feb 2, 2026
FRATES JAMES M

Chief Financial Officer

Bought $101.4KSold $2.37M
13 tradesLast: Feb 2, 2026
Klee Justin B.

Co-Chief Executive Officer

Sold $6.42M
17 tradesLast: Feb 2, 2026
Mazzariello Gina

Chief Legal Officer

Sold $870.2K
14 tradesLast: Feb 2, 2026
Firestone Karen

Director

Bought $299.3K
4 tradesLast: Dec 23, 2025
Bedrosian Camille L

Chief Medical Officer

Sold $379.6K
5 tradesLast: Dec 1, 2025
Zeiher Bernhardt G

Director

Bought $37.0K
1 tradesLast: Mar 20, 2025
MILNE GEORGE M JR

Director

Bought $719.8KSold $1.12M
4 tradesLast: Sep 3, 2024
Quimi Daphne

Director

Bought $9.4K
2 tradesLast: May 15, 2024
Yeramian Patrick D

Chief Medical Officer

Sold $3.72M
8 tradesLast: Jan 9, 2024
Olinger Margaret

Chief Commercial Officer

Bought $130.0KSold $87.2K
3 tradesLast: Jan 6, 2023
ALS Invest 1 B.V.

10% Owner

Sold $1.25M
4 tradesLast: Jul 6, 2022
Cheng Isaac

Director

Bought $125.0K
1 tradesLast: Jan 6, 2022
FONTEYNE PAUL R.

Director

Bought $75.0K
1 tradesLast: Jan 6, 2022